Cetirizine, Phenylephrine and Paracetamol Suspension

Acetaminophen is a pain reliever and fever reducer.
Cetirizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, Cetirizine, and phenylephrine is a combination medicine used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.
Acetaminophen, Cetirizine and Phenylephrine may also be used for purposes not listed in this medication guide.

• Headache
• Nasal congestion
• Sinus Symptoms caused by allergies
• Fever
• Muscle pain
• Sciatica
• Common cold and flu

Paracetamol is an effective analgesic-antipyretic (relieves mild to moderate pain) and a weak anti-inflammatory agent.
Absorption: It is readily absorbed from the g.i. tract with peak plasma concentrations occurring about 10 to 60 min. after oral administration.
Distribution: It is distributed into most body tissues.
Elimination: Approximately 80% of acetaminophen is excreted in the urine after conjugation and about 3% is excreted unchanged.
Half life: 1 to 4 hours.

Cetirizine HCL is potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
Absorption: Mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours post dose was observed for cetirizine.
Protein binding: Very high (93%) plasma protein binding.
Half life: 8.3 hours.

Phenylephrine Hydrochloride iis a sympathomimetic amine that acts predominantly on α-adrenergic receptors. In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells.
Absorption: Completely absorbed after oral administration. Peak serum concentrations are achieved approximately 0.75-2 hours following oral administration.
Protein binding 95% binding-plasma proteins
Metabolism: Undergoes extensive first-pass metabolism in the intestinal wall and extensive metabolism in the liver.
Route of elimination: PPhenylephrine and its metabolites are mainly excreted in urine.
Half life: 2.1 to 3.4 hours.

• Dizziness, drowsiness
• Mild headache, blurred vision
• Dry mouth, nose, or throat
• Constipation

• Contraindicated if the patient have a known hypersensitivity to any of the ingredient in this product.
• Contraindicated during pregnancy and breast feeding.
• Contraindicated in patients suffering from asthma, COPD, diabetes, liver, kidney and heart ailments.